Ketcher 10261612222D 1 1.00000 0.00000 0 32 36 0 0 0 999 V2000 6.4051 -7.7358 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4122 -8.7358 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2819 -9.2297 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1371 -7.7237 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1443 -8.7236 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6794 -8.2126 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2676 -7.2298 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0859 -7.4079 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.0975 -9.0258 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.6794 -8.2055 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1731 -7.3358 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1856 -9.0679 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1732 -7.3288 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1855 -9.0607 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6794 -8.1912 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6918 -9.9375 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 12.6670 -6.4592 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.1609 -5.5967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6547 -4.7272 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1609 -5.6039 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5788 -6.4170 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5673 -4.7990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6257 -6.1148 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6184 -5.1149 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8696 -3.8458 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8209 -6.7084 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5355 -7.2420 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6731 -7.7482 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5285 -6.2420 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8035 -7.2543 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6589 -5.7482 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7965 -6.2543 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7 1 2 0 0 0 7 4 1 0 0 0 1 2 1 0 0 0 2 3 2 0 0 0 3 5 1 0 0 0 8 4 1 0 0 0 4 5 1 0 0 0 5 9 2 0 0 0 8 6 2 0 0 0 9 6 1 0 0 0 11 10 1 0 0 0 12 10 2 0 0 0 13 11 2 0 0 0 14 12 1 0 0 0 15 13 1 0 0 0 15 14 2 0 0 0 6 10 1 0 0 0 12 16 1 0 0 0 13 17 1 0 0 0 17 18 1 0 0 0 18 19 2 0 0 0 21 20 1 0 0 0 22 20 2 0 0 0 23 21 1 0 0 0 24 22 1 0 0 0 24 23 2 0 0 0 18 20 1 0 0 0 22 25 1 0 0 0 23 26 1 0 0 0 28 27 1 0 0 0 29 27 2 0 0 0 30 28 2 0 0 0 31 29 1 0 0 0 32 30 1 0 0 0 32 31 2 0 0 0 1 27 1 0 0 0 M END > CHEBI:133824 > GNF6702 > An aromatic amide obtained by formal condensation of the carboxy group of 2,4-dimethyl-1,3-oxazole-5-carboxylic acid with the aromatic amino group of 4-fluoro-3-[6-(pyridin-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]aniline. A proteasome inhibitor known to be active against the three parasites that cause Chagas disease, leishmaniasis and sleeping sickness. > 3 > GNF-6702; GNF 6702 > N-{4-fluoro-3-[6-(pyridin-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl}-2,4-dimethyl-1,3-oxazole-5-carboxamide > C22H16FN7O2 > 429.407 > 429.13495 > 0 > C1(=CN2N=C(N=C2N=C1)C=3C=C(C=CC3F)NC(=O)C=4OC(=NC4C)C)C=5N=CC=CC5 > InChI=1S/C22H16FN7O2/c1-12-19(32-13(2)26-12)21(31)27-15-6-7-17(23)16(9-15)20-28-22-25-10-14(11-30(22)29-20)18-5-3-4-8-24-18/h3-11H,1-2H3,(H,27,31) > WXZFCGRYVWYYTG-UHFFFAOYSA-N > 28255207 > GNF6702 > 27501246 $$$$