Ketcher 04251611062D 1 1.00000 0.00000 0 52 55 0 1 0 999 V2000 8.2983 -5.3967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1691 -4.8940 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0397 -5.3967 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.9104 -4.8940 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7810 -5.3967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6519 -4.8940 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 13.5226 -5.3967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3933 -4.8940 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.2640 -5.3967 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 16.1347 -4.8940 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0055 -5.3967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8763 -4.8940 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 18.7469 -5.3967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.6178 -4.8940 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2983 -6.4021 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 20.4247 -5.3892 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1689 -6.9047 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1688 -7.9102 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2981 -8.4130 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.4274 -7.9102 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4276 -6.9048 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.6179 -3.8884 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 17.0055 -6.4020 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.3933 -3.8886 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.7810 -6.4020 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.1691 -3.8887 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 16.1347 -3.8886 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9104 -3.8886 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7469 -6.4021 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5226 -6.4021 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.9523 -4.5488 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 21.4300 -5.3990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0099 -3.3833 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7826 -3.3850 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7826 -2.3795 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6412 -1.8837 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6411 -0.8783 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7703 -0.3757 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9117 -0.8714 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9119 -1.8769 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8706 -3.8804 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7413 -3.3777 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7416 -2.3724 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8808 -1.8752 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0101 -2.3779 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3933 -6.9049 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.2547 -6.4073 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3933 -7.9101 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.6176 -6.9049 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4821 -6.4058 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.6178 -7.9102 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.7003 -5.8743 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 2 3 1 0 0 0 3 4 1 0 0 0 4 5 1 0 0 0 5 6 1 0 0 0 6 7 1 0 0 0 7 8 1 0 0 0 8 9 1 0 0 0 9 10 1 0 0 0 10 11 1 0 0 0 11 12 1 0 0 0 12 13 1 0 0 0 13 14 1 0 0 0 1 15 1 0 0 0 14 16 1 0 0 0 15 17 1 0 0 0 17 18 1 0 0 0 18 19 1 0 0 0 19 20 1 0 0 0 20 21 1 0 0 0 15 21 1 0 0 0 14 22 2 0 0 0 11 23 2 0 0 0 8 24 2 0 0 0 5 25 2 0 0 0 2 26 2 0 0 0 10 27 1 1 0 0 4 28 1 1 0 0 13 29 1 6 0 0 7 30 1 6 0 0 16 31 1 0 0 0 16 32 1 0 0 0 31 32 1 0 0 0 27 33 1 0 0 0 28 34 1 0 0 0 34 35 1 0 0 0 35 36 2 0 0 0 36 37 1 0 0 0 37 38 2 0 0 0 38 39 1 0 0 0 39 40 2 0 0 0 35 40 1 0 0 0 33 41 2 0 0 0 41 42 1 0 0 0 42 43 2 0 0 0 43 44 1 0 0 0 44 45 2 0 0 0 33 45 1 0 0 0 30 46 1 0 0 0 46 47 1 0 0 0 46 48 1 0 0 0 29 49 1 0 0 0 49 50 1 0 0 0 49 51 1 0 0 0 16 52 1 1 0 0 M END > CHEBI:65347 > carfilzomib > A synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma > 3 > N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide > carfilzomib > Kyprolis > C40H57N5O7 > 719.911 > 719.42580 > 0 > C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C([C@@]1(OC1)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)CCC3=CC=CC=C3)=O)N4CCOCC4 > InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1 > BLMPQMFVWMYDKT-NZTKNTHTSA-N > 868540-17-4 > 12488950 > 868540-17-4 > D08880 > Carfilzomib > 19348473; 20937826; 21905015; 22235146; 22411899; 22507794; 22507799; 22555973; 22621161; 22645181; 22665938; 22726549; 22727391; 22734651; 22761464; 22763387 $$$$