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(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone |
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CHEBI:70020 |
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(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone |
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A tetrahydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 5, 7, 3' and 5' and a geranyl group at position 8. Isolated from Macaranga bicolor, it exhibits inhibitory activity against breast cancer resistance protein. |
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This entity has been manually annotated by the ChEBI Team.
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Molfile
XML
SDF
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InChI=1S/C25H28O6/c1-14(2)5-4-6-15(3)7-8-19-20(28)12-21(29)24-22(30)13-23(31-25(19)24)16-9-17(26)11-18(27)10-16/h5,7,9-12,23,26-29H,4,6,8,13H2,1-3H3/b15-7+/t23-/m0/s1 |
CUAHQWHCZQIDAM-KETROQBRSA-N |
CC(C)=CCC\C(C)=C\Cc1c(O)cc(O)c2C(=O)C[C@H](Oc12)c1cc(O)cc(O)c1 |
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Macaranga bicolor
(NCBI:txid396452)
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Methanol-Dichloromethane (1:1) extract of dried, ground plant material
See:
PubMed
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metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
breast cancer resistance protein inhibitor
Any inhibitor of breast cancer resistance protein (ABCG2).
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View more via ChEBI Ontology
Outgoing
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(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone
(CHEBI:70020)
has functional parent
(2S)-flavanone
(CHEBI:15606)
(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone
(CHEBI:70020)
has role
breast cancer resistance protein inhibitor
(CHEBI:72771)
(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone
(CHEBI:70020)
has role
metabolite
(CHEBI:25212)
(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone
(CHEBI:70020)
is a
3'-hydroxyflavanones
(CHEBI:48024)
(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone
(CHEBI:70020)
is a
tetrahydroxyflavanone
(CHEBI:38742)
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(2S)-2-(3,5-dihydroxyphenyl)-8-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one
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21312877
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Reaxys Registry Number
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Reaxys
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21275386
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PubMed citation
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Europe PMC
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