tetrabenazine |
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CHEBI:9467 |
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A racemate consisting of equal amounts of (3R,11bR)- and (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one. An adrenergic uptake inhibitor, it was formerly used as an antipsychotic, but it is now used mainly for the treatment of various movement disorders including chorea, ballism, dystonias, and tardive dyskinesia. |
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This entity has been manually annotated by the ChEBI Team.
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adrenergic uptake inhibitor
Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
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antipsychotic agent
Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
adrenergic uptake inhibitor
Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
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View more via ChEBI Ontology
Outgoing
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tetrabenazine
(CHEBI:9467)
has part
(3R,11bR)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
(CHEBI:64029)
tetrabenazine
(CHEBI:9467)
has part
(3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
(CHEBI:64030)
tetrabenazine
(CHEBI:9467)
has role
adrenergic uptake inhibitor
(CHEBI:35640)
tetrabenazine
(CHEBI:9467)
has role
antipsychotic agent
(CHEBI:35476)
tetrabenazine
(CHEBI:9467)
is a
racemate
(CHEBI:60911)
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rac-(3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
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tetrabenazina
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ChemIDplus
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tetrabenazine
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ChemIDplus
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tetrabenazinum
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ChemIDplus
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1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one
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NIST Chemistry WebBook
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1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-one
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ChemIDplus
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2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine
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ChemIDplus
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Ro 1-9569
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ChemIDplus
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TBZ
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ChEBI
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Tetrabenazine
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KEGG COMPOUND
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Nitoman
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DrugBank
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Xenazine
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DrugBank
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58-46-8
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CAS Registry Number
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ChemIDplus
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58-46-8
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CAS Registry Number
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NIST Chemistry WebBook
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9356999
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Reaxys Registry Number
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Reaxys
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10686169
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PubMed citation
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Europe PMC
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19929707
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PubMed citation
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Europe PMC
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20442355
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PubMed citation
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Europe PMC
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20869622
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PubMed citation
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Europe PMC
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21487088
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PubMed citation
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Europe PMC
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9040721
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PubMed citation
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Europe PMC
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