CHEBI:231364 - riviciclib

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name riviciclib
ChEBI ID CHEBI:231364
Definition A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a (2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl group at position 8 and by a chlorine at the 2' position. A cyclin-dependent kinase inhibitor that exhibits anti-cancer properties.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Delphine Zhou
Supplier Information
Download Molfile XML SDF
Formula C21H20ClNO5
Net Charge 0
Average Mass 401.840
Monoisotopic Mass 401.10300
InChI InChI=1S/C21H20ClNO5/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3/t12-,14+/m1/s1
InChIKey QLUYMIVVAYRECT-OCCSQVGLSA-N
SMILES [H][C@]1(CCN(C)[C@H]1CO)C1=C2OC(=CC(=O)C2=C(O)C=C1O)C1=CC=CC=C1Cl
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing riviciclib (CHEBI:231364) has role antineoplastic agent (CHEBI:35610)
riviciclib (CHEBI:231364) has role EC 2.7.11.22 (cyclin-dependent kinase) inhibitor (CHEBI:82665)
riviciclib (CHEBI:231364) is a N-alkylpyrrolidine (CHEBI:46775)
riviciclib (CHEBI:231364) is a dihydroxyflavone (CHEBI:38686)
riviciclib (CHEBI:231364) is a monochlorobenzenes (CHEBI:83403)
riviciclib (CHEBI:231364) is a primary alcohol (CHEBI:15734)
IUPAC Name
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-4H-chromen-4-one
INNs Sources
riviciclib WHO MedNet
riviciclib WHO MedNet
riviciclib WHO MedNet
riviciclibum WHO MedNet
Synonyms Sources
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-4H-1-benzopyran-4-one IUPAC
P-27600 free base ChEBI
P276-00 (free base) ChEBI
P276-00 free base SUBMITTER
Manual Xref Database
US2010152129 Patent
View more database links
Registry Number Type Source
920113-02-6 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
17363486 PubMed citation Europe PMC
17363487 PubMed citation Europe PMC
19151776 PubMed citation Europe PMC
21216463 PubMed citation Europe PMC
22083267 PubMed citation Europe PMC
22873289 PubMed citation Europe PMC
23075291 PubMed citation Europe PMC
23343191 PubMed citation Europe PMC
23414419 PubMed citation Europe PMC
24051085 PubMed citation Europe PMC
25816934 PubMed citation Europe PMC
27171036 PubMed citation Europe PMC
29370702 PubMed citation Europe PMC
30733087 PubMed citation Europe PMC
32858336 PubMed citation Europe PMC
35068399 PubMed citation Europe PMC
37015886 PubMed citation Europe PMC
Last Modified
09 May 2024